JWHolding

Nutrition & IV drug​

Nutrition & IV drug

• Development of nutritional status improvement products and patient disease treatment products based on JW Life Sciences' liquid product research and production know-how

Nutrition product systematization technology.​

Has experience in developing various fluid formulations.

• Multi-chamber product manufacturing technology​
• Owns liquid manufacturing technology such as liquid emulsion / antibiotic​

Various experience and expertise in Nutrition stabilization.​

Formulating research system.​

Product stability research tehcnology​​

Product stability research tehcnology​​

International regulatory product development​​

International regulatory product development technology.​​

Nutrition

Developing various types of products containing glucose, amino acids, lipids and trace elements required to improve patient nutrition​

Injectables

Developing liquid therapeutics for various fields.​

Representative number of each business company

	Description	Major Products	Container Types
Basic I.V. Solutions	Supply of Water, electrolytes, calorie	NS, DW, HS (50, 100, 500 & 1000, 3000 mL) PP (50, 100 mL)	Non-PVC Bag PP Bottle
I.V. Drugs & Specialty Solutions	Anti-infective I.V. therapy	Quinolone Osmotic Therapy Plasma Expander Irrigation	Non-PVC Bag PP Bottle
Nutritional Solutions	Supply of Nutrition	Amino Acid Lipid TPN	Non-PVC Bag Non-PVC 2-Chamber Bag Non-PVC 3-Chamber Bag
Dialysis	Dialysis for patients in renal failure	HD	PE Bottle

Intellectual property

• KR10-16723470000 (2016.10.28) : 수액 제제(INFUSION PREPARATION)

Container closure system​

Container closure system

• Development of liquid packaging and hospital supplies through JW Life Science's development of liquid product packaging materials and research on high functional (oxygen / moisture barrier) materials

Container Closure System means the entire packaging component that contains and protects the formulation.

CCS consists of a primary packaging component that is a part of the package that is in direct contact with the formulation and a secondary packaging component that is a part that is not in direct contact with the formulation.

The HP R&D Center of JW Life Sciences has achieved a global level of CCS through continuous research and expertise based on the know-how accumulated by a team of experts leading domestic IV solution related technologies.

Nutrition container diversification technology​​

• Experience in developing various fluid formulations
• Knowledge of physicochemical properties and functionalities of each container​
• Knowledge of physicochemical properties and functionalities of each container​

Container and accessory development technology​​

Various eco-friendly medicine containers, patients, and customized accessory development technology

JW Nutrition Container​​

Although bottle containers have been mainly used since the production of IV solution, plastic containers have appeared all over the world due to problems such as bottle weight and risk of damage. Plastic containers can be classified into PVC and Non-PVC PVC is an infusion container material that is widely used worldwide because of its low cost and easy molding. However, DEHP, a plasticizer used to improve flexibility in the manufacturing process during molding, is a kind of environmental hormone, and risks in human body such as reproductive toxicity are emerging. In addition, chloride of PVC has been found to make dioxin, a carcinogen when incinerated. In Korea and abroad, regulations have been made on PVC using phthalate plasticizers such as DEHP in IV solution containers.

Non-PVC is a general term for materials other than PVC. In the IV solution container, PP, PE or its composites are used, which has the advantages of being an environmentally friendly material, but requires high technical skills in processing. JW started the research of Non-PVC containers in the 1990s and developed its own technology for non-PVC IV solution containers, leading the advancement of domestic IV solution containers. In addition, JW has acquired the US FDA in 2003 and CFDA in China in 2004, and is actively engaged in overseas business such as exporting non-PVC IV solution film to China.

Nutrition Container Requirements​​​

To be used as an infusion container, the following conditions must be satisfied.

• It must be non-toxic and not reactive with the contents.
• Moisture and gas must not be permeated.
• It should be free of pyrogenic substances and sterile.
• It must be resistant to external temperature, light, air and UV.
• Have sufficient strength to maintain the stability of the product during transport, handling, storage, sterilization, use and easy storage / transportation.
• Material acquisition should be easy and economical.
• It should be transparent and convenient to use.

Classification	Glass	PVC	Non-PVC
	Bottle	Bag	Plastic Bottle	Bag
Material	Silicon	PVC	PE or PP	PP or composite
Advantage	Low price Good barrier property	Low price Good flexibility	Upright type Accurate capacity display line	Good drug stability Good flexibility
Disadvantage	Aluminum elution Difficulties in handling	Limited drug stability DEHP (Environmental Hormone) Elution Dioxin (carcinogen) emission	Poor flexibility	High price Low processability

Bag & Film​​

Material :polypropylene multilayer plastic

Form :Mono bag, 2CB, 3CB etc

Specification :50ml, 100ml, 250ml, 500ml, 1000ml, 2000ml 외

• Minimize the fine particles in solution by FFS (Form Fill Seal) machine method.
• Container making, filling and sealing are automated in one machine.
• Easy to insert fluid set and drug mixture by using rubber stopper system.

2-Port system​​

• Two ports are distinguished to increase safety during drug infusion.

Tamper seal method

• Tamper seal is attached to check the opening.
• Various printing is possible so that product can be classified by color.
• There is a free space for easy drug mixing.

Multi Chamber System

• Multi Chamber is a system that has multiple chambers such as glucose chamber, amino acid chamber and lipid chamber in one fluid container. The most advanced product with improved chemical stability and consumer convenience. Requires high technical skills and consumer can use after mixing chambers. JW Life Sciences produces and sells 2CBs of glucose and amino acids and 3CB products of glucose, amino acids and lipids.

Plastic Bottle

PP Bottle

Material :Polypropylene
Lightweight and easy to handle as it is not damaged by physical impact.

Specification :50mL, 100mL​

• Labeling : Free expression in the form of stickers.​
• Hanger is attached to the label and can be used upside down if necessary.
• There is a free space for easy drug mixing.​

Perfusate container

Material : Polypropylene

Specification :1,000mL​

Dialysate container​

Material :HDPE

Specification : 5.5L, 7L, 10L, 12.6L​​

It is an optimal design considering the stability of the product.​

Intellectual property​​​

• KR1012738940000 (2013.06.05) : Ring-off Type Medical Cap and Cleaning Container for Medical Devices Employing Thereof
• KR10-17998690000 (2017.11.15) : Multi chamber medical container
• KR20-04822470000 (2016.12.28) : Nutrition Bag Packing Box for AN INFUSION SOLUTION BAG
• KR20-04856000000 (2018.01.24) : FILLING PORT FOR AN INFUSION SOLUTION BAG
• KR2004855990000 (2018.01.24) : Nutrition Bag (INFUSION SOLUTION BAG)